Metrohm^® Karl Fischer Automation

Direct injection

Karl Fischer automation - injects the sample directly into the KF cell for analysis

Automation of Karl Fischer with direct injection of sample High sample throughput For coulometric or volumetric determination Easy handling FDA 21 CFR Part 11-compliant The Metrohm 815 Sample Processor with optional KF direct inject kit completely automates the Karl Fischer analysis for either coulometric or volumetric analysis. The system will pipet the sample, inject it directly into the KF cell, determine the moisture content and even automatically exchange the KF reagent when it is exhausted.

The sample rack accommodates up to 160 sample vials, which are sealed with a septum cap to limit the uptake of moisture before the sample is analyzed. With our revolutionary Dosino^® liquid handling device, the system will pipet from 0.1 ml to 4.0 ml of the sample, which can be varied from sample to sample—and inject it directly into the KF cell. A Metrohm coulometer or volumetric titrator can then analyze the moisture content in the sample.

The KF direct inject system comes with an exclusive automated reagent exchange package, featuring the Dosino for a simple exchange of the KF reagent once it is exhausted.

The system will regularly monitor the KF cell to determine if the reagent needs replacement. If the reagent needs to be exchanged, the system will automatically empty and rinse the vessel, add fresh solution and condition the cell before continuing with the next sample—without any operator intervention. This results in shorter conditioning times and limited user handling of KF solutions.

The system is operated with tiamo™, Metrohm’s new, progressive titration software. The intuitive user interface can be streamlined for individual users to simplify views and minimize training time.

Powerful data handling tools include:

• Secure results database featuring a quick filter
• Customizable reports
• Export to LIMS
• Automatic database backup

tiamo is 21 CFR Part 11- and GLP-compliant with central user administration, complete traceability of all results through a secure audit trail and system password protection.