Heidolph^® Synthesis 1 for Solid Phase Synthesis

General Advantages

For chemical reactions and processes by immobilization of the material with a resin. Synthesis 1 allows for adding samples, splitting off from the resin, filtration of by-products and purification of the product.

Operational advantages

• Exceptional visual control of reaction due to circular design of reaction block
• Quick and easy access to all samples due to revolving reaction block
• Simple dismantling of reaction vessels
• Reaction vessels feature valves and eliminate the use of needles
• Reaction vessel screw fittings allow access for cleaning and filter replacement
• Washing and recovery of product through vacuum filtration
• All reaction vessels feature bottom valves for draining of washing solvent and for product collection
• Central connection and distributor for vacuum and inert atmosphere

Interchangeable reaction blocks

• Choose 3 different reaction blocks for different sample volumes and quantities:
  • Solid 16 for 16 reaction vessels, 42 ml each
  • Solid 20 for 20 reaction vessels, 25 ml each
  • Solid 24 for 24 reaction vessels, 8 ml each
• Setting of 4 different reaction temperatures due to 4 heating zones with individual heat control
• Additional condensation zone allows for refluxing of solvents; optional chiller required
• Superior heat transfer from reaction block to sample
• Additional samples can be added via septa

Reaction vessels for solid phase synthesis

• Transparent reaction vessels allow clear visibility of samples
• Exceptional chemical resistance due to PTFE & PFA material
• Resin will not stick to inner side of reaction vessel
• Bottom part of reaction vessel accommodates filter, valve and tubing connection to Waste Cube
• Upper part of reaction vessel accommodates septa and tubing connection for evacuation and inert atmosphere
• Vessel design ensures optimal septa fixing
• Reaction vessel screw fittings allow easy access for cleaning and filter replacement
• PTFE coating of septa gives acid resistance

Waste Cube

• Suction device to collect washing solvents in a vessel
• After synthesis process the product will be recovered by vacuum and collected in test tubes
• Clear visibility at all times due to transparent glass door

Note
Samples and resins in required pore size can be bought from a local specialized chemical supplier.