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Chemical Stability of the Brinkmann®
Bottletop Dispenser and the Brinkmann Bottletop Buret
Bottletop dispensers are used in the lab for dispensing a wide range
of different solvents from glass or stainless steel containers. These
dispensers have to meet various requirements. For example, they must not
give off any substances which may disturb trace analysis, have cytotoxic
properties, distort optical tests or influence chromatographic methods
and residue analysis.
Even after prolonged contact with the solvent, the materials of the dispenser
must not be affected nor bind the solvent non-specifically. This means
that there are very high demands on the chemical resistance of bottletop
dispensers.
The Brinkmann Bottletop Dispenser and Brinkmann ChemSaver®
Bottletop Dispenser are made of material which is particularly resistant
to chemicals. Only parts made of PFA (perfluor alkoxy), PTFE (polytetrafluor
ethylene), boron silicate glass 3.3 and platinum / iridium come into contact
with the solvents. The adapter rings for the screw connection are made
of PP (polypropylene).
The following pages include an example on the use of a Bottletop Dispenser
for residue analysis in the lab of a food manufacturer as well as a list
of the materials of which the Bottletop Dispenser is made and their chemical
resistence.
Dispensing ultrapure solvents for residue analysis at the
Hipp plant in Pfaffenhofen, Germany
The residue analysis of foodstuffs places high demands on the solvents
and the inertness of the lab equipment used to detect, for example, even
the smallest traces of pesticides.
Therefore, contamination caused by lab equipment has to be avoided under
all circumstances.
A series of experiments were performed to test the suitability of the
Bottletop Dispenser for food analysis. Aim: to determine whether the Bottletop
Dispenser is inert to the solvents commonly used in this field.
Two examples of these experiments are described briefly
below:
Test A
100 ml of the solvent acetonitrile (CH3CN) were drawn from a larger
supply with a Bottletop Dispenser, evaporated in a rotation evaporator
and then dissolved in 1 ml of the solvent i-octane. This sample was
examined using gas Chromatography.
Result: No other peak could be found in addition
to the solvent peak. Therefore, no substances had been released from
the Bottletop Dispenser.
Test B
A specific amount of the herbicide atrazine (50 pg / ml) 1)
was added to a sample treated as in test A as a comparative standard
for pesticides. In order to detect minute amounts of pesticide, the
background in the chromato-gram must consistently be as low as possible.
Result: The atrazine peak can be clearly
seen in the chromatogram without any ghost bands. This shows that minute
amounts of pesticides can be detected with this system.
1) (EG drinking water limit: 100 pg / ml) signal time solvent peak A
signal time solvent peak B Atrazine peak
For each chemical, 2 figures are stated. The figure on the left is stability
at a test temperature of +20°C, the figure on the right is the stability
at +50°C. Salts were tested as almost saturated solutions. All data
are recommondations without guarantee. 1 = resistant 2 = sensitive (raw
material is affected after longer contact) 3 = incompatible
| CHEMICALS |
PFA |
PTFE |
Boron silicateglass 3.3 |
Bottletop Buret & Dispenser
can be used |
PP Adapter rings |
| Acetaldehyde |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 3
*1 |
| Acetic acid, 50% |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Acetone *5
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Acetonitrile *5
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
2 /
3 *1 |
| Acrylonitrile |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
2 /
3 *1 |
|
Adipic acid |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Allyl alcohol |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Aluminum chloride
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Aluminum hydroxide
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Amino acids |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Ammonia |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Ammonium chloride
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Ammonium hydroxide,
30% |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| n-Amyl acetate |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
2 /
3 *1 |
| Amyl alcohol |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Amyl chloride |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
3 /
3 *1 |
| Aniline
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Aqua regia *2
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
2 /
3 *1 |
| Barium chloride (BaCl2) |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Benzaldehyde |
1 / 2 |
1 / 1 |
1 / 2 |
1 / 1 |
1 / 1 |
| Benzene |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 2
*1 |
| Benzine |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 2
*1 |
| Benzyl alcohol |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Biuret reagent |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Boric acid |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Bromine |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Bromoform (Tri Methanbromid) |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
|
n-Butanol |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| n-Butyl acetate |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 2
*1 |
| Calcium chloride |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
|
Carbon disulphide |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Carbon tetrachloride
|
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Chloroacetic acid
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Chromic acid, 10% |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Chromic acid, 50%
*2 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 2
*1 |
| Chromic sulfuric acid,
concentrated *2 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Cresol |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 2
*1 |
| Cupric sulphate |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Decahydronaphtalene
|
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Dibutyl phtalate |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 2
*1 |
| Dichlorobenzene |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
2 /
3 *1 |
| Dichlorethane (Ethyl
dichloride)*5 |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
2 /
3 *1 |
| Dichlormethane (Methylene
chloride)*5 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Diethylene glycol
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Diethyl ether |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
2 /
3 *1 |
| Dimethylformamide
|
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 3
*1 |
| 1.4-Dioxan |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 2
*1 |
| Ethanol 100% (Ethyl
alcohol) |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Ethyl acetate |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Ethylene oxide |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
2 /
3 *1 |
| Formaldehyde, 40%
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Formic acid, 98-100%
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Fuel oil |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Glycerol *4 |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Glycol |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| n-Hexane |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
2 /
3 *1 |
| Hydrochloric acid 35% *5
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Hydrochloric acid 37% *5
|
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 3
*1 |
| Hydrofluoric acid,
40% |
1 / 1 |
1 / 1 |
3 / 3 |
3 / 3 |
1 / 1 |
| Hydrogen peroxide,
30% *3 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 |
1 / 1 |
| Iodine-Potassium iodide
sol. |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Isobutanol (Isobutyl
alcohol) |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Isopropanol (Isopropyl
alcohol) |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Isopropyl benzene
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
2 /
3 *1 |
| Lactic acid / Lactate
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Magnesium chloride
(MgCl) |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Mercury |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Mercury (I) chloride
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Methanol (Methyl alcohol)
*5 |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Methyl propyl ketone
|
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 2
*1 |
| Nitric acid, 10% |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Nitric acid, 50% |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
2 /
3 *1 |
| Nitric acid, 70% |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Nitrobenzene |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Octane / iso octane
|
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Oil of turpentine
|
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Oxalic acid |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Pentane (n- / Iso-)
*5 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Perhlorethylene |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Perchloric acid, 10% |
1 / 2 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 3
*1 |
| Phenol, 100% |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Phosphoric acid, 85%
|
1 / 1 |
1 / 1 |
2 / 3 |
2 / 3 |
1 / 1 |
| Potassium chloride
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Potassium hydroxide
, 50% |
1 / 1 |
1 / 1 |
1 / 2 |
1 / 2 |
1 / 1 |
| Potassium permanganate
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Propanol |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Propylene glycerol
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Propylene oxide |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Pyridine |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 2
*1 |
| Salicylaldehyde |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Salicylic acid |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Scintillation cocktail
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
2 /
3 *1 |
| Silver acetate |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Silver nitrate |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Sodium acetate |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Sodium dichromate
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Sodium hydroxide,
50% |
1 / 1 |
1 / 1 |
1 / 2 |
1 / 2 |
1 / 1 |
| Sulphuric acid, 60%
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Sulphuric acid, 98%
|
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Tartaric acid |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Tenside (Tween-, Trition
X-, Brij-dilutions) |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Tetrachloroethylene
|
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Tetrahydrofuran |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Toluene |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
2 /
3 *1 |
| Trichloroacetic acid,
10% |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Trichloroethane |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Trichloroethylene
|
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Trichlorofluorethane *5
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Tricloromethane (Chloroform)
*5 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 2 |
2 / 2
*1 |
| Triethylene glycol
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Trifluoroacetic acid (fuming; strongest
of halogenized acids)*5 |
3 / 3 |
1 / 1 |
3 / 3 |
3 / 3 |
3 / 3 |
| Tripropylenglycol
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Urea |
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Vinylidene chloride
|
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Xylene |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3
*1 |
| Zinc chloride, 10%
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
| Zinc sulphate, 10%
|
1 /
1 |
1 /
1 |
1 / 1 |
1 / 1 |
1 /
1 |
|
 |
